Endomysial Antibody:
Why Endomysial Antibody Test?
CLINICAL INFORMATION
Gluten is a protein found in wheat, barley, rye etc. Endo-Mysial AntibodyTest (EMA Test) is done for early detection of Celiac Disease. EMA Test screens for immunoglobulins (auto-antibodies called as ‘Endomysial Antibodies’, (that attack healthy cells i.e inner lining of the intestines causing irritation and swelling) in the blood towards Gluten (where immune system responds abnormally against Gluten protein - produceGliadin antibodies), hence known as Celiac disease (auto-immune disease). In such patients, it is also identified that Endomysial Antibodies elicits (abnormally provokes) immune response against (self-antigen) tissue trans-glutaminase (an enzyme that cross-links and stabilizes extracellular matrix protein). This endomysial antibody test can also be used to screen other autoimmune diseases like Dermatitis herpetiformis (chronic blistering skin condition – blisters characterized with formation of itchy boils –with watery fluid). Clinical manifestations may present with auto-immune disease related to liver, thyroid and skin. Moreover, a physician may order for an EMA Test with the signs and symptoms which may also include aggravation of discomfort in the gastrointestinal tract after ingestion of Gluten diet with abdominal pain (bloating sensation in the abdomen), chronic irregular bowel movements, flatulence, blood in stool, long-standing diarrhea and also, sometimes accompanied with extra-gastrointestinal manifestations such as chronic anaemia, fatigue, joint pain (due to calcium) and fractures, weight loss, extreme weakness, mouth ulcers, psychological disorders like depression, deficiency of IgA antibodies etc. If left untreated, Celiac disease can lead to complications such as mal-absorption of nutrients, In children – it causes stunted growth (due to loss of appetite) along with long-standing constipation and/or severe vomiting and irritability, In Pregnant women - increased risk of abortion, birth defects in pregnancies and can also lead to cancer (Intestinal cancers). Hence Anti-Endomysial antibodies or Anti-Endomysial Antibodies prove to be sensitive markers for Celiac Disease and other related similar auto-immune conditions (involved with EMA - Endomysial Antibodies or Auto-antibodies).
General Instructions:
Sample Requirement: Specimen - Blood sample collected from the vein. Test Preparation: None.
NOTE - Sample for specimen collections may vary based on the patient’s condition/cases according to the patient’s presenting complaints/signs or symptoms:
SPECIMEN REQUIREMENT (Special or Rare Cases) - As instructed and guided by Physician / Clinician / Pathologist / as per Laboratory’s requirements, according to procedures and protocols.
This Multi-Specialty Clinical Referral Laboratory RTDIAGNOSTICS provides precise and accurate tests with an extensive range of testing services to the medical centres to help in the diagnosis and identification of pathology in the test specimens for infectious diseases and also to evaluate the function of organ systems of the patient. It prevents further complications and helps to stabilize and restore health to near normalcy at the earliest without delay.
