Coombs Direct:
Why Coombs direct Test?
CLINICAL INFORMATION
Coombs direct test helps to detect antibodies that target the surface of RBCs, causes destruction of red blood cells leading to anemia eg jaundice in the newborn (hemolytic disease of the newborn), drug induce hemolysis such as penicillin, cephalosporin, piperacillin, etc, diseases like lupus, lymphoma, chronic lymphicytic leukemia, infections like mononucleosis, mycoplasma pneumonia, etc, reaction to blood transfusion, etc. Hence this test helps in confirmation of diagnosis and also to rule out to screen another differential diagnosis (possibilities), such as auto-immune disorders. Clinical manifestations mimics signs and symptoms for anemia like low RBCs, shortness of breath, cold and clammy extremities, pale skin, dizziness, back pain, dark urine, heart disorders like irregular heartbeat, heart murmur, heart failure, and other symptoms include jaundice, enlarged liver and/or spleen, etc. Coombs test screens for certain antibodies that can lyse the RBCs causing hemolytic anemia. Conditions that may interfere with test results are medications such as penicillin (antibiotics), anti-inflammatory medications, antiplatelet drugs such as clopidogrel, chemotherapy medications, etc.
General Instructions:
Sample Requirement: Specimen - Blood sample collected from the vein. Test Preparation: None.
NOTE - Sample for specimen collections may vary based on the patient’s condition/cases according to the patient’s presenting complaints/signs or symptoms:
SPECIMEN REQUIREMENT (Special or Rare Cases) - As instructed and guided by Physician / Clinician / Pathologist / as per Laboratory’s requirements, according to procedures and protocols.
Sample Requirement: Blood Sample taken from the vein
Test Preparation: None
This Multi-Specialty Clinical Referral Laboratory RT DIAGNOSTICS provides precise and accurate tests with an extensive range of testing services to the medical centers to help in the diagnosis and identification of pathology in the test specimens for infectious diseases and also to evaluate the function of organ systems of the patient. It prevents further complications and helps to stabilize and restore health to near normalcy at the earliest without delay.
