Bilirubin Indirect
Bilirubin is a pigment and it’s a waste product produced by the breakdown of heme (Component of Hemoglobin). Finally, it is processed by the liver and eliminated. This test evaluates the Bilirubin level to examine Liver function, disorders, and Hemolytic Anemia. Bilirubin is a yellow pigment present along with the blood. It is synthesized by the catabolism of red blood cells. . Bilirubin levels in the blood help to test jaundice, liver diseases, and anemia. Altered levels of bilirubin(direct and indirect)in the blood help to diagnose conditions such as JAUNDICE, liver diseases (obstructive and non-obstructive jaundice), infections such as malaria leading to anemia. Bilirubin testing evaluation of bilirubin is preferred when affected by conditions such as liver disorders, hemolytic anemia, congenital conditions and jaundice in newborns (physiological), etc.
Bilirubin (Indirect):
Why Indirect Bilirubin test? Bilirubin is made by our body when the red blood cells break down. This test checks at the health of patient’s liver eg excessive RBC lysis like malaria, liver cirrhosis etc.
CLINICAL INFORMATION :
Indirect Bilirubin test is performed in suspected patients with conditions such as hemolytic anemia, cirrhosis, etc. Conjugated bilirubin is in a soluble form (can be excreted in urine and stool) and it is called direct bilirubin and indirect bilirubin is un-conjugated form of bilirubin and is insoluble because it is without glucuronidation, hence cannot be excreted by the body. Elevated levels of indirect bilirubin indicates liver disease or damage hence unable to undergo glucuronidation process or excessive RBC lysis that produces excess bilirubin so the liver is unable to handle this extra load to conjugate in soluble form to excrete. The general causes can be divided into pre-hepatic (hemolytic anemia) or certain drugs, hepatic (alcoholic fatty liver and hepatitis) and post-hepatic issues (bile duct obstruction, gall stones, and pancreatitis) also type of bilirubin can be conjugated form or unconjugated form of bilirubin. This test is usually done for ‘JAUNDICE’ (yellow coloration of eyes and skin) in newborn and liver related diseases, infectious diseases like malaria (excess RBC break down), hepatitis and liver diseases in alcoholics, etc, and other related pathologies. This test is suggested in patients with symptoms such as swelling causing enlarged abdomen, chills, fever, chest pain, weakness, lightheadedness, fatigue, and nausea, etc. Other associated tests include the Vandenberg test for direct or conjugated bilirubin, indirect or unconjugated bilirubin by kit method, colorimetric method, and spectrometric methods, etc.
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General instructions:
Sample Requirement: Specimen –24 Hours Urine sample. Test Preparation: None.
NOTE - Sample for specimen collections may vary based on the patient’s condition/cases according to the patient’s presenting complaints/signs or symptoms:
SPECIMEN REQUIREMENT (Special or Rare Cases) - As instructed and guided by Physician / Clinician / Pathologist / as per Laboratory’s requirements, according to procedures and protocols.
This Multi-Specialty Clinical Referral Laboratory RTDIAGNOSTICS provides precise and accurate tests with an extensive range of testing services to the medical centers to help in the diagnosis and identification of pathology in the test specimens for infectious diseases and also to evaluate the function of organ systems of the patient. It prevents further complications and helps to stabilize and restore health to near normalcy at the earliest without delay.
