Apolipoprotein B/ A1 Ratio
Apolipoprotein-B and Apolipoprotein A involved in the metabolism process of lipids and which are the main constituent protein in the High-Density Lipoprotein (HDL) and Very Low-Density Lipoprotein (VLDL) respectively. This test measures Apolipoprotein B and A₁ and calculates the ratio to detect the risks of occurrence in Cardio Vascular Diseases (CVD).
APOLIPOPROTEIN B/A₁ RATIO:
Why ApolipoproteinB/A1 test?
CLINICAL INFORMATION :
ApolipoproteinB/A1ratio is a potential marker of plasma atherogenicity since this ratio represents the balance between Apo-B rich atherogenic particles and Apo- A1 rich anti-atherogenic particles. Hence this ratio is considered to be a marker of cardiovascular risk.
Apo-A1 measures A1 protein (the main component of HDL) that has a specific role in the metabolism of lipids. Hence other than Apo-A1 other lipid tests as a part of the lipid profile may be ordered to determine the risk of developing cardiovascular diseases. Thus low Apo-A1 level signifies the risk of heart diseases like atherosclerotic cardiovascular disease eg. Coronary artery disease and that too when specifically the levels of Apo-lipoprotein-B –An atherogenic lipoprotein (which directly corresponds to LDL-C and to non-HDL-C) are high. Apo B is a primarily integral apoprotein required for the formation of low-density lipoprotein – LDL (bad cholesterol). Apo B-100 serves as a signal for cellular binding and internalization of LDL particles by apo B/E receptors. Apolipoprotein-B is the primary apolipoprotein of chylomicrons (Apo B-48), VLDL (Apo B-100), IDL, LDL (Apo B-100), and lp(a). Apo-B-48 is composed of 2521 amino acids and is essential for the formation of chylomicrons and Apo-B-48 is also responsible for the absorption of dietary fat from the intestine. Thus high levels of Apo-B can lead to plaques causing atherosclerosis and heart diseases.
General instructions:
Sample Requirement: Specimen - Blood sample collected from the vein. Test Preparation: None.
NOTE - Sample for specimen collections may vary based on the patient’s condition/cases according to the patient’s presenting complaints/signs or symptoms:
SPECIMEN REQUIREMENT (Special or Rare Cases) - As instructed and guided by Physician / Clinician / Pathologist / as per Laboratory’s requirements, according to procedures and protocols.
This Multi-Specialty Clinical Referral Laboratory RTDIAGNOSTICS provides precise and accurate tests with an extensive range of testing services to the medical centers to help in the diagnosis and identification of pathology in the test specimens for infectious diseases and also to evaluate the function of organ systems of the patient. It prevents further complications and helps to stabilize and restore health to near normalcy at the earliest without delay.
