Anti Thrombin III Activity

ANTI-THROMBIN III – ACTIVITY:

Why Anti-Thrombin III Activity test?

CLINICAL INFORMATION :

Anti-thrombin activity test measures how well the protein inhibits thrombin. Antithrombin is a member of serine protease inhibitor (serpine) superfamily. Anti-Thrombin IIIor Thrombate III or heparin cofactor-1 or AT is a protein that is a non-vitamin-K dependent protease that helps control blood clots. It inhibits coagulation by neutralizing the enzyme activity of thrombin (blood clotting factors IIa, IXa, Xa). It measures the activity or function and the amount of anti-thrombin in the patient’s blood is quantified to evaluate the cause for excessive blood clotting. ThisAnti-thrombin-III (AT-III)test determines the amount of AT-III present in the body and hence it is ordered to diagnose anti-thrombin protein deficiency which might result in causing increased blood clots than normal. Some of the causes of acquired antithrombin deficiency are a liver failure (liver cirrhosis), nephrotic syndrome (too much anti-thrombin excreted in urine resulting in AT deficiency), metastatic tumors, disseminated intravascular coagulation, severe trauma, burns, chemotherapy with asparaginase and generalized clotting, and Sepsis – a bleeding disorder that is often associated with infection in the bloodstream, etc. Complications include deep vein thrombosis (DVT), phlebitis, thrombophlebitis, pulmonary embolus (blood clot in the lung), blood clot in arteries that may lead to heart attack and/ or stroke. Other tests that may be performed along with this test are protein-C deficiency, protein-S deficiency, Factor V Leiden, and Factor II G20210A. 

General instructions:

Sample Requirement: Specimen - Blood sample collected from the vein. Test Preparation: None.

NOTE - Sample for specimen collections may vary based on the patient’s condition/cases according to the patient’s presenting complaints/signs or symptoms:

SPECIMEN REQUIREMENT (Special or Rare Cases) - As instructed and guided by Physician / Clinician / Pathologist / as per Laboratory’s requirements, according to procedures and protocols.    

This Multi-Specialty Clinical Referral Laboratory RTDIAGNOSTICS provides precise and accurate tests with an extensive range of testing services to the medical centers to help in the diagnosis and identification of pathology in the test specimens for infectious diseases and also to evaluate the function of organ systems of the patient. It prevents further complications and helps to stabilize and restore health to near normalcy at the earliest without delay.