ANTI-SMITH ANTIBODY:
Why Anti-Smith Antibody test?
CLINICAL INFORMATION :
Anti-Smith Antibody test is a highly specific antibody is considered as a marker antibody for systemic lupus erythematosis (SLE), however, these antibodies are found only in 20% of patients with SLE and hence this test is performed along with an anti-nuclear antibody test. This test is performed to diagnose some cases of SLE and mixed-connective tissue disease (MCTD). Early symptoms indicative of lupus is a photo-sensitive rash (Malar Rash – A butterfly rash that develops in response to exposure to the sun- particularly in the face are arms) can develop large blisters called bulbous lupus rash, unexplained fever, and pain, swelling and stiffness of multiple joints. Other symptoms include raised red patches on the skin, ulcers in mouth and nose, inflammation in the lining of heart and lungs (pericarditis in heart, pleurisy in lungs – pain in the chest while deep breathing resulting in shortness of breath and/or may lead to pulmonary embolism), seizures, proteinuria, Raynaud’s phenomenon – purple or pale fingers or toes when exposed to cold or stress, etc. A few causes of SLE include drug-induced lupus-like medications such as steroids, hydroxychloroquine, cyclophosphamide, azathioprine, methotrexate, isoniazid, hydralazine, procainamide, minocycline, quinidine, drugs used for inhibiting tumor necrosis factor such as etanercept, infliximab, adalimumab, rituxan, or rituximab for the treatment of rheumatoid arthritis and lymphoma, etc. some of the complications of untreated SLE conditions may get progressively worse and may lead to lupus nephritis (kidney damage), stroke, heart attack, etc.
General instructions:
Sample Requirement: Specimen - Blood sample collected from the vein. Test Preparation: None.
NOTE - Sample for specimen collections may vary based on the patient’s condition/cases according to the patient’s presenting complaints/signs or symptoms:
SPECIMEN REQUIREMENT (Special or Rare Cases) - As instructed and guided by Physician / Clinician / Pathologist / as per Laboratory’s requirements, according to procedures and protocols.
This Multi-Specialty Clinical Referral Laboratory RTDIAGNOSTICS provides precise and accurate tests with an extensive range of testing services to the medical centers to help in the diagnosis and identification of pathology in the test specimens for infectious diseases and also to evaluate the function of organ systems of the patient. It prevents further complications and helps to stabilize and restore health to near normalcy at the earliest without delay.
