ANTICENTROMERE ANTIBODY:
Disorders in the immune system produce anticentromere antibody (ACA) which is one of the antinuclear antibody, produced against self-antigens. This Antibody mistakenly affects the CENTROMERE (A Component in the chromosome). This test evaluates ACA Level in the blood to diagnose Cutaneous Scleroderma (hardening of the skin). Signs and symptoms are calcinosis detected by palpation for subcutaneous nodules and confirmed by radiographs and biopsy for deposit studies and for histopathological studies. Complications are pulmonary hypertension. Other tests for scleroderma include non-specific indicators such as anemia, thrombocytosis, elevated ESR, and elevated CRP levels. Calcinosis – evaluate serum calcium and phosphorous levels to exclude metabolic disturbances (usually this process of calcinosis is not associated with calcium and phosphorous abnormalities). Esophageal dysmotility – patients with ANAs are anti-centromere antibodies have more involvement with esophageal dysmotility. Sclerodactyly – a thyrotrophin test may help exclude the presence of thyroid disease as a potential cause for edematous or rough skin. Tests for Telangiectasia and Raynaud phenomenon are also checked as a part of this diagnosis.
Why Anti-centromere antibody test?
CLINICAL INFORMATION :
ANTI-CENTROMERE ANTIBODY (ACA) TEST is primarily ordered to help diagnose the auto-immune disorder limited to cutaneous scleroderma, a form of systemic scleroderma and CREST syndrome. ACA are auto-antibodies specific to centromeres. They occur in some autoimmune diseases, frequently in systemic scleroderma (formerly called CREST syndrome). ACA is a positive test for systemic scleroderma and involves cutaneous involvement and can cause lung fibrosis. ACAs are also found associated with primary biliary cirrhosis with portal hypertension.
General instructions:
Sample Requirement: Specimen - Blood sample collected from the vein.Test Preparation: None.
NOTE - Sample for specimen collections may vary based on the patient’s condition/cases according to the patient’s presentingcomplaints / signs or symptoms:
SPECIMENREQUIREMENT (Special or Rare Cases) - As instructed and guided by Physician / Clinician / Pathologist / as per Laboratory’s requirements, according to procedures and protocols.
This Multi-Specialty Clinical Referral Laboratory RTDIAGNOSTICS provides precise and accurate tests with an extensive range of testing services to the medical centers to help in the diagnosis and identification of pathology in the test specimens for infectious diseases and also to evaluate the function of organ systems of the patient. It prevents further complications and helps to stabilize and restore health to near normalcy at the earliest without delay.
