Anti CCP (Cyclic Citirullinated Peptide) IgG

ANTI-CCP IgG:

Why Anti-CCP IgG test?

CLINICAL INFORMATION :

ANTI-CCP IgG test is performed to screen for autoantibodies against the cyclic citrullinated peptide (CCP) in the blood produced in rheumatoid arthritis. Anti-CCP IgG is performed along with rheumatoid factor (RF) to confirm Rheumatoid arthritis. Apart from these positive test results for RF and Anti-CCP antibody tests, even sero-negative cases (without the presence of antibodies against CCP or RF) are present with rheumatoid arthritis. These levels can be elevated in rheumatologic conditions associated with inflammatory arthritis, such as systemic lupus erythematosis (SLE). Anti-citrullinated protein antibodies (ACPAs) are autoantibodies that are directed against proteins that are citrullinated is a useful tool for diagnosis, as it serves biomarkers in the majority of rheumatoid arthritis patients. During inflammation, the amino acid arginine is converted into citrulline in protein such as vimentin by a process called citrullination. Vimentin is secreted and citrullinated by macrophages in response to apoptosis or by pro-inflammatory cytokines such as tumor necrosis factor-alpha (THF-alpha). Hence genetically modified citrullinatedvimentin (MCV) is used in ELISA to detect Rheumatoid arthritis patients. Symptoms of rheumatoid arthritis are joint pain, joint stiffness, joint swelling, loss of cartilage, and loss of joint function and deformities.  Other tests include ESR and CRP helps to access measure inflammation, X-rays, MRI scans, etc.

General instructions:

Sample Requirement: Specimen - Blood sample collected from the vein. Test Preparation: None.

NOTE - Sample for specimen collections may vary based on the patient’s condition/cases according to the patient’s presentingcomplaints / signs or symptoms:

SPECIMENREQUIREMENT (Special or Rare Cases) - As instructed and guided by Physician / Clinician / Pathologist / as per Laboratory’s requirements, according to procedures and protocols.   

This Multi-Specialty Clinical Referral Laboratory  RTDIAGNOSTICS provides precise and accurate tests with an extensive range of testing services to the medical centers to help in the diagnosis and identification of pathology in the test specimens for infectious diseases and also to evaluate the function of organ systems of the patient. It prevents further complications and helps to stabilize and restore health to near normalcy at the earliest without delay.